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2 Short Courses in FBAT/PBAT in Boston and Boulder http://www.biostat.harvard.edu/~pbat/index.htm Course Date and Location: ● June 2-3, 2008 at the Harvard School of Public Health, Boston MA. Application Deadline: May 7, 2008. ● January 8-9, 2009 at the University of Colorado, Boulder, CO Application Deadline: Dec 1, 2008. Course Organizers and Faculty: ● Nan Laird, Christoph Lange: Department of Biostatistics, Harvard School of Public Health ● Matt McQueen: University of Colorado, Boulder, CO Topics: ● Family-based association test (FBATs) ● Multi-marker, haplotype tests ● Analysis of complex phenotypes: repeated-measurements, time-to-onset data, mulitvariate phenotypes ● Testing strategies and genome-wide association analysis ● CNV analysis in family-based studies ● Integrative Genomics in family-based association studies ● Power and design considerations for family-based association studies Description: The increasing availability of genetic marker data, especially SNP’s, has made investigations of genetic associations between marker data and disease commonplace. This course will focus on family based designs for association studies; these designs use information on affected individuals and their relatives, most commonly parents and/or siblings. Family based designs are attractive in that they test for both association and linkage thus avoiding difficulties with population stratification and admixture. In addition, the population information in the data can be used for model building and screening. This course will give a very brief introduction to the basic concepts of genetic association in general, and family based designs in particular. The focus of the course is on the FBAT/PBAT methodology and how to use the packages. An overview of the topics discussed can be found in Laird NM and Lange C “Family Based Designs in the Age of Large-Scale Gene-Association Studie s,” Nature Reviews/Genetics, 2006, 7:385-394. The orientation of the course is practical rather than theoretical. It combines lectures and computer tutorials with hands on data analysis using the FBAT and PBAT packages. Both packages can be accessed from the FBAT/PBAT web pages http://www.biostat.harvard.edu/~clange/default.htm and http://www.biostat.harvard.edu/~fbat/default.html. P2BAT is available through the R-package that can be downloaded at http://www.r-project.org. The GoldenHelix PBAT version will be posted on the course web-page 2 weeks before to the course. A special website will be created for the course so that all course materials will be available there. Note: Both GoldenHelix PBAT and P2BAT will be taught in this course. Intended audience: This course is intended for clinicians, epidemiologists, data analysts, geneticists, and statisticians involved in the analysis of genetic data. Familiarity with genetic concepts as well as background in basic statistics at the level of linear/logistic regression is highly desirable. Participants are encouraged to bring their own data sets; check the FBAT web page for details on file format. We also strongly recommend that participants read the manuals before attending the course. Application, Registration and Fees. The course fee is $500.00; this covers course materials, coffee breaks and two lunches. Applicants will be accepted on a first come first serve basis; the course is limited to 45 participants. Full time doctoral students may obtain a reduced fee of $150 with a letter certifying student status from your institution. Please fill out the Registration Form (Follows Preliminary Schedule Below) and return via email to Jelena T. Follweiler ([log in to unmask]). To download the course information and Registration Form, go to one of the websites listed above. REGISTRATION FORM Short Course on FBAT and PBAT June 2-3, 2007, Harvard School of Public Health, Boston MA 02115 Please email completed form to Jelena T. Follweiler ([log in to unmask]). Do NOT send registration fee until your acceptance has been confirmed. Once you have been accepted, the full fee is required to hold your place. Please note that once your application has been accepted, you must also send the optional course dinner fee if dinner is desired. Sorry, but credit cards cannot be accepted. Name: Affiliation/Address: Email Address: Position (e.g. M.D. in Psychiatry, Postdoc in Epidemiology, etc.): Experience in Genetic Analysis, Family-Based Association Studies, etc.: Previous Coursework in Statistics/Biostatistics: Other Relevant Experience: Software packages you are familiar with, INCLUDING FBAT and PBAT: What do you hope to gain from attending this course? REGISTRATION FORM Short Course on FBAT and PBAT Jan 8-9, 2008, University of Colorado, Boulder, CO Please email completed form to Matt McQueen ([log in to unmask]). Do NOT send registration fee until your acceptance has been confirmed. Once you have been accepted, the full fee is required to hold your place. Please note that once your application has been accepted, you must also send the optional course dinner fee if dinner is desired. Sorry, but credit cards cannot be accepted. Name: Affiliation/Address: Email Address: Position (e.g. M.D. in Psychiatry, Postdoc in Epidemiology, etc.): Experience in Genetic Analysis, Family-Based Association Studies, etc.: Previous Coursework in Statistics/Biostatistics: Other Relevant Experience: Software packages you are familiar with, INCLUDING FBAT and PBAT: What do you hope to gain from attending this course?