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A postdoctoral position is available to work on longitudinal multimodal neuroimaging data in the framework of a multidisciplinary research program held by Dr Gaël Chételat and Dr Béatrice Desgranges. This program associates neuropsychological evaluation, FDG-PET, activation and resting state fMRI as well as structural MRI in various populations including healthy subjects, and patients with neurodegenerative dementia (e.g. Alzheimer’s disease). Its main objectives are both to improve early diagnosis of the diseases and to contribute to our knowledge of their underlying processes. The study will focus on highlighting the effects of normal and pathological aging on brain activity and functional connectivity during rest and during cognitive activity over time, the relationships between the different neuroimaging modalities (MRI, fMRI and PET) and the comparison of their accuracy in predicting patient’s clinical evolution. The position would be particularly devoted to the development and application of new multivariate analysis approaches such as independent component analyses to be applied to fMRI data and assess their relationships with other imaging modalities. The successful candidate will be welcomed in the Inserm Unit E0218 / U923 directed by Francis Eustache and Béatrice Desgranges, and located at the Cyceron PET/MRI Center in Caen, France. The successful applicant will join a large multidisciplinary team (including scientists, engineer, technicians, doctors, psychologists, and PhD students) focusing much of its research on the cerebral bases of human memory and its disorders using complementary neuropsychological and neuroimaging techniques including MRI (3T) and FDG-PET. This position offers the opportunity to work in a high quality research environment, with strong clinical and scientific collaboration. Applicants should have a PhD in a relevant area of neuroimage processing, be comfortable with the Unix operating system, and demonstrate knowledge and experience in computational MRI processing and mathematical/statistical modelling/analysis. We are seeking an applicant with solid grounding in applied mathematics, statistics, and neuroimaging data acquisition and analysis, with demonstrated productivity, as well as programming skills (MATLAB, C++). Good English language skills, good communication skills and an interest in multidisciplinary teamwork are required. Salary: 1900 euros / month, net Duration: two years starting in Mars/April 2008, possibility of expansion Application (application letter + CV + 2 reference letters) should be sent to: [log in to unmask] Deadline: Applications will be considered until the post is filled Questions with respect to this position may be emailed directly to Dr. Chételat. SELECTION CRITERIA Essential criteria: • A PhD or equivalent in a relevant area of neuroimage processing; • Previous experience with neuroimaging data acquisition, processing and analysis; • Demonstrated mathematical/statistical expertise and experience in applications in neuro-image modelling/analysis; • Demonstrated programming expertise and fluency in C/C++ and/or Matlab programming language; • Good organizational and planning skills; • Demonstrated ability to work effectively as part of team as well as independently; Preferred criteria • Available for two years at least from Mars/April 2008, although the schedule could be adapted in particular situation; • Demonstrated experience in working with patients and competency in research within a clinical environment; • Good interpersonal and communication skills, including preparation of scientific presentations, reports and journal articles; • Fluent in written and spoken English. Applicants should systematically address the selection criteria in their application.