Hi sear SPMers, I'm calculating the lateralization index and I wonder how to realize: (1) variable statisctical thresholds across subjects - for each individual the selected threshold should correspond to a fixed number of activated voxels in certain regions. (2) mean activation of the 5% of voxels showing the highese level of activation in certain ROI. (3) % signal change analysis with a given threshold for inclusion (i.e. only the voxels that exceed the given activation level are included to calculate). Reference: Jansen et al., 2006. The assessment of hemispheric lateralization in functional MRI--robustness and reproducibility. PMID: 16904913 Your help will be very much appreciated!!! Qing