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Dear FSL list (Ifm sorry to send a garbled e-mail. I send you an e-mail again.) I am attempting segmentation of brains of infant chimpanzees using FAST. I succeeded to segment gray and white matter regions in the older subjects. However, the white matter regions seemed to be overestimated while the gray matter regions seemed to be underestimated in younger infants under one year old. I would like to ask you to give me any suggestion that I should try. I would also like to learn the method to segment the unmyelinated white, and myelinated white matter regions using FAST? The brains of infant chimpanzees were scanned under T1 weighted, and the data were processed as follows. (1) Scans were corrected for fluctuations in average intensity using SUSAN. (2) Brains were aligned to anterior commisure]posterior commisure orientation in transverse view using MRIcro. (3) Cerebral portions of brains were extracted using BET (option: -R -m - s -r 50 -f 0.3 -g 0.2) and FSLview. (4) Gray and white matter regions were segmented using FAST (option: -t 1 - c 3 -a -A -od, -os -ob -i 16 -l 200 -v 1- 5). I appreciate for your help in advance. Tomoko Sakai Primate Research Institute Kyoto University ____________________________________________________________________ Tomoko Sakai Primate Research Institute, Kyoto University Brain Research SectionEDepartment of Behavioral and Brain Sciences Inuyama, Aichi 484-8506, JAPAN TEL. +81-568-63-0567 (Administrative Office) FAX. +81-568-63-0085 E-mail: [log in to unmask] ____________________________________________________________________