There was a good BMJ article claiming that stains cause LVF as well as peripheral neuropathy , both of which would probably be blamed on the condition for which the statin was given. I think cholesterol targets are madly low at the moment and I do not trust the evidence as statins have too much financial value to drug companies.
----- Original Message -----
From: [log in to unmask] href="mailto:[log in to unmask]">Colin Brown
To: [log in to unmask] href="mailto:[log in to unmask]">[log in to unmask]
Sent: Tuesday, November 20, 2007 2:57 PM
Subject: Re: Simple, sensible Lipids protocol

<<Jeff Green wrote on 18 November 2007 23:22
Pravastatin (and rosuva) are more hydrophillic and perhaps less likely to penetrate the muscle and cause myalgia.>>

Or the brain and cause nightmares, or the even worse SE alleged here:
http://www.spacedoc.net/forgetfullness_disorientation_confusion_statins.htm


<<And on Sun 18/11/2007 22:55 Jeff Green wrote:
Similarly Rosuva doesn't have the evidence base for saving lives or the safety record.>>

But rosuva is definitely a statin, (and the most potent one) so should benefit from a class effect by default.  Unlike ezetimibe.

Remember the massive pharma- and media-driven evidence-war when it came out?
With "evidence" driven by $billion marketing and Stock Exchange deals, perhaps all that we should do is be alert to individual patient ADRs and do N-of-1 re-challenges to check them out - and Yellow-card them.


Colin Brown

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