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<<Jeff Green wrote on 18 November 2007 23:22 Pravastatin (and rosuva) are more hydrophillic and perhaps less likely to penetrate the muscle and cause myalgia.>> Or the brain and cause nightmares, or the even worse SE alleged here: http://www.spacedoc.net/forgetfullness_disorientation_confusion_statins.htm <<And on Sun 18/11/2007 22:55 Jeff Green wrote: Similarly Rosuva doesn't have the evidence base for saving lives or the safety record.>> But rosuva is definitely a statin, (and the most potent one) so should benefit from a class effect by default. Unlike ezetimibe. Remember the massive pharma- and media-driven evidence-war when it came out? With "evidence" driven by $billion marketing and Stock Exchange deals, perhaps all that we should do is be alert to individual patient ADRs and do N-of-1 re-challenges to check them out - and Yellow-card them. Colin Brown ********************************************************************** This message may contain confidential and privileged information. If you are not the intended recipient please accept our apologies. Please do not disclose, copy or distribute information in this e-mail or take any action in reliance on its contents: to do so is strictly prohibited and may be unlawful. Please inform us that this message has gone astray before deleting it. Thank you for your co-operation. NHSmail is used daily by over 100,000 staff in the NHS. Over a million messages are sent every day by the system. To find out why more and more NHS personnel are switching to this NHS Connecting for Health system please visit www.connectingforhealth.nhs.uk/nhsmail **********************************************************************