CALL FOR PAPERS
COMPUTATIONAL STATISTICS & DATA ANALYSIS
Special Issue on
COMPUTATION AND CLINICAL TRIALS
http://www.elsevier.nl/locate/csda
Guest Editors:
Lutz Edler, Jae Won Lee, Martina Mittlböck, Joyce Niland and
Norbert Victor
We are inviting submissions for the 1st special issue of Computational
Statistics and Data Analysis that address statistical methods and
computational data analysis approaches in the design and/or analysis
of clinical studies, covering both, the pharmaceutical clinical trials
for the detection and characterization of better treatments as well as
the explorative clinical studies for the understanding of diseases and
their treatment.
With the appearance of larger data sets both in terms sample size and
in terms of number of patients' characteristics measured the need of
new appropriate and efficient computational methods and data analysis
approaches has become urgent during the last decade. Whereas
extraordinary efforts and large investments were devoted to increase
the quality of clinical data much less has been invested in
computational statistics methods fit for clinical research purpose.
The special issue will include:
* design and data analysis for Phase I,II, III trials
* pharmacokinetics and dose finding studies
* exploratory analysis and prognostic factors
* cross-over studies
* diagnostic studies and biomarker evaluation
* longitudinal data analyses and safety evaluation
* pharmacogenetic and pharmocogenomic data
* predictive factors and medical decision making
* treatment allocation and adaptive designs
* meta analyses and interpreting clinical trial results
* Bayesian methods and population models
* medical informatics and bioinformatics
* competing risk and multistate models
* disease modelling and public health
For this special issue we are now soliciting papers that address
statistical and computational aspects of the design or analysis of
clinical studies. Theoretical papers or papers with simulation as the
main contribution are not suitable for the special issue. However
overviews are welcome if they provide new and original work able to
promote research.
In addition, the journal offers authors the possibility to enhance
their articles by including data sets along with the online article.
These files will appear embedded in the article on ScienceDirect at
www.sciencedirect.com/science/journal/01679473. The files will be
freely available at this site. Copyright of the files will remain with
the authors and their use will require the citation of the related
article (journal, author, title and date of the publication). No
liability is assumed by the contributors, the publisher, or the IASC.
Submission must contain original unpublished work and both, a
computational and a medical or clinical component, possibly combined
with a substantive application. This can include comprehensive and
intellectually synthetic review papers that is not being submitted for
publication elsewhere.
The deadline for submissions is 22 December 2007. Notification of
decisions will be given by 15 March, 2008. Authors who are uncertain
about the suitability of their papers should contact one of the
special issue editors. All submissions must contain original
unpublished work not being considered for publication elsewhere.
Papers should be submitted using the Elsevier Electronic Submission
tool EES: http://ees.elsevier.com/csda
In the EES please chose the special issue on "Computation and Clinical
Trials".
Submissions will be refereed according to standard procedures for
Computational Statistics and Data Analysis (CSDA). Information about
the journal can be found at http://www.elsevier.com/locate/csda. The
CSDA is indexed in Science Citation Index (Web of Science).
The special issue editors:
Lutz Edler
Department of Biostatistics, German Cancer Research Center,
Heidelberg, Germany
E-mail: [log in to unmask]
Jae Won Lee
Department of Statistics, Korea University, Seoul, South Korea
E-mail: [log in to unmask]
Martina Mittlböck
Core Unit for Medical Statistics and Informatics, Medical University
of Vienna, Vienna, Austria
E-mail: [log in to unmask]
Joyce Niland
City of Hope Comprehensive Cancer Center, Division of Information
Sciences Duarte, California, USA
E-mail: [log in to unmask]
Norbert Victor
Institute of Medical Biometry and Informatics, University of
Heidelberg, Germany
E-mail: [log in to unmask]
