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To follow from Ged, I use the attached script to calculate the x-y-z shift to apply to the image so that it overlaps the MNI template (see help/comments on applying to the image). Best wishes, Paul DRC SPM wrote: > Hi Amir, > > This is probably an issue that has come up on the mailing list a > couple of time, briefly: SPM5's unified segmentation is more sensitive > to the initial rigid alignment of the images with the template/priors > than SPM2's normalisation was. > > Use Check Reg, with the template and your images, right click your > image and select "reorient this image" from the context menu (I'm > working from memory here, but hopefully that's correct). You don't > need perfect AC-PC alignment, but you do need rough agreement of brain > orientation. > > Hope that helps, > Ged. > > > On 12/10/2007, Amir Tahmasebi <[log in to unmask]> wrote: > >> Dear SPM experts, >> >> I am using SPM5's unified segmentation technique for warping. It works >> fine on 17 out of 21 subjects but it doesn't properly deform the other 4 >> subjects' data. However, when using SPM2's normalization, all 21 subjects >> are properly deformed to match ICBM template. I tried different values (1, >> 10, 100) for the warping regularisation but still couldn't make it work. I >> appreciate it if you could kindly help me with this case. I can send you >> one of the datasets if you want to try. Thanks in advance. >> >> Regards, >> Amir Tahmasebi >> >> > >