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I have no direct experience, but it's an interesting question. Here is one study. Note the statement: "The glucose-dependent lactose tolerance test was found to be of satisfactory diagnostic value in nondiabetic subjects and was useless for diagnostic purposes in diabetics." Lerch MM, Rieband HC, Feldberg W, Matern S. Digestion. 1991;48(2):81-8. Concordance of indirect methods for the detection of lactose malabsorption in diabetic and nondiabetic subjects. (Abstract) In order to collect data on (1) the prevalence of lactose malabsorption and (2) the value of indirect diagnostic methods for hypolactasia in diabetics, we compared lactose tolerance tests using serum glucose, serum galactose (after oral ethanol intake) and breath hydrogen excretion as diagnostic cutoff in 144 nondiabetic and 46 diabetic subjects. A good rate of concordance was found for the hydrogen breath test and galactose-dependent lactose tolerance test. The glucose-dependent lactose tolerance test was found to be of satisfactory diagnostic value in nondiabetic subjects and was useless for diagnostic purposes in diabetics. Lactose malabsorption was no more frequent in diabetics than in controls and lactose intolerance was found to be less frequent in the diabetic group. A distinction between hypolactasia and other gastrointestinal disorders in diabetics is possible by ambulatory indirect tests. Regards, H.V. Markle Dallas huiquan lou <[log in to unmask]> Sent by: Clinical biochemistry discussion list <[log in to unmask]> 10/12/2007 01:18 PM Please respond to huiquan lou <[log in to unmask]> To [log in to unmask] cc Subject lactose tolerance test for diabetic patients Hello, Please review the following results for lactose tolerance test: Fast Glucose 19 mmol/L Glucose -1/2 HR 23.0 mmol/L Glucose-1 HR 24.2mmol/L Glucose-1.5HR 23.9mmol/L Glucose-2HR 25.0mmol/L The cutoff in our lab: glucose rise >1.7 mmol/L: Adequate lactase activity Glucose rise <1.1 mmol/L: lactase deficiency Questions: Is lactose tolerance test valid for patients with diabetes? Can we exclude lactase deficiency from these results? Thanks Amy Lou Clinical Chemist Department of Laboratory Medicine Queen Elizabeth Hospital Charlottetown Canada Express yourself with free Messenger emoticons. Get them today! ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/