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Hi,

I have done some VBM analysis (normalised with modulation) and for each 
subjects output there is a 
"subjectID"_seg.txt file

Within this file there are three numbers. I am assuming these are the GM, 
WM and CSF volumes and that the units of these numbers are cm^3?

If i wanted to assess whether there was a global change in GM, WM or CSF 
between repeat scans on  a subject group, would it be valid to use these 
figures in a two sample t-test?  

Best wishes

John