 |
 |
Dear All, If anyone would be happy to share their reference range for Roche vitamin B12, I would be much obliged. We are currently using 140 - 640 pg/ml, derived from both in-house data and consultation with other Roche users. However, Roche are recommending 191-663 pg/ml in their kit insert (data derived from a German population), although they do state that differences exist with respect to population and dietary status. If we were to move to the Roche recommended values, 11% of our total requests for B12 would be "deficient" as opposed to 4.3% using our current lower cut-off value 140 pg/ml. We have always had a population with lower than average B12 levels and this was also seen when we used Abbott Architect in the past. I worry about this lower value in the reference range as those who fall below it are usually treated with B12 injections (perhaps unnecessarily). On the other context, we could be missing B12 deficiency as a cause of neurological features etc. Any advice (and your reference range) would be much appreciated. Best wishes Peter This email is confidential and intended solely for the use of the individual(s) to whom it is addressed. Any views or opinions presented are solely those of the author and do not necessarily represent those of Southern Health and Social Care Trust. If you are not the intended recipient, be advised that you have received this email in error and that any use, dissemination, forwarding, printing, or copying of this email is strictly prohibited. If you have received this email in error please notify the sender. ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/