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Two separate trace element issues Patient with Gitelman's syndrome developed significant hyponatraemia taking spironolactone and was switched to amiloride; both preparations failed to control hypomagnesaemia. Is there a better approach? Patient had aluminium dental crown fitted and noticed electrical tingling in mouth and unpleasant taste; two weeks later had diarrhoea and other vague symptoms including muscle fatigue; he is a physicist, working in an industrial chemistry company specialising in corrosion, and wondered if he had an electrical cell formed by recent mercury/silver amalgam filling and the aluminium crown, causing electrolysis of aluminium and hence aluminium toxicity. Crown removed four weeks ago, feeling better. Any help gratefully received. John Frater Consultant Chemical Pathologist University Hospital of Hartlepool ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/