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You just need to "coregister only". Reslicing anatomical images is really only needed when using software outside SPM, which may not be able to understand the orientation information in the image headers (or mat files for older SPM versions). Best regards, -John -----Original Message----- From: SPM (Statistical Parametric Mapping) [mailto:[log in to unmask]] On Behalf Of Olga Prilipko Sent: Thursday, August 09, 2007 6:07 PM To: [log in to unmask] Subject: [SPM] Coregistration and reslicing question Dear all, I have a basic question concerning Coregistration step: when coregistering the anatomical image to the meanepi should I "Coregister and reslice" or can I "coregister only" since I am doing a normalisation afterwards? Thank you very much. Olga