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Dear All. Is there any disadvantage of using the anomalous data set to do refinement? I recently solved a structure using Se-SAD. The anomalous data set was used in refinement with CNS. It gives decent result. Because traditionaly, after phasing we will use the nonanomalous data set in refinement. I am just curious if anybody has tried using the anomalous one and what's the difference between using anomalous and nonanomalous data in refinement.. Thank You Sun