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Dear all,
 
this must be a basic question for must of you, but I need your qualified opinion.
 
I am running an spm analysis with a cannonical 2 by 3 design, and I wonder which of these two approaches is the appropriate:
 
After specifying the matrix design with six conditions (i.e., A1, A2, A3, B1, B2, B3) I might run for the first level analysis:
 
A1: 1 0 0 0 0 0
A2  0 1 0 0 0 0
.     0 0 1 0 0 0
.     0 0 0 1 0 0
.     0 0 0 0 1 0
A6  0 0 0 0 0 1
 
which represents the averages on each condition per subject
 
at the second level, then, I might contrast, for example, A1>B1 with the *com images in a full factorial anova
 
the second approach would be doing direct contrasts at the first level:
 
E.g, A1>B1  1 0 0 -1 0 0 per subject, and then, performing per-specific-contrast one sample t tests at the second level with all the respective subject's com images.
 
which of these two approaches is the most appropriate? I think the second one is more sensitive per specific comparisons while keeping the advantages of the random effects test. is not it?
 
thanks a lot
 
Roberto