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Hi Jorge, > I'm trying to co-registrate an MRI image with a > Siemens CT-PET using the coregistrate option of SPM > but I can't. The program returns this message: > > Undefined function or variable "ibig" This variable is used in the optimisation routine, spm_powell.m; from a quick glance, I think the problem of it possibly being undefined exists only in SPM2, both SPM5 and SPM99 (where powell is a subfunction of spm_mireg.m) define it before first use. You might want to try using the SPM5 version of this code, if not SPM5 altogether... It's probably simple to change SPM2's version to pre-define the variable, but I don't have time to check properly what value it should be defined to (probably numel(p) as in SPM5, but take care!). > Do this option need some overlap between the images to > function? because my 3D images origins are very > distants. Not sure, but it would probably help. Under SPM5, you could use Check Reg, right-click and select the reorient image option; under SPM2, I think if you load each image with Display you can roughly align their origins. Hope that helps, Ged.