Hi James,

Apologies, I am not familiar with some of the language you are using. When you say a twin design, are you talking about having two FMRI sessions for each subject? In which case you need to do something akin to a paired t-test:
http://www.fmrib.ox.ac.uk/fsl/feat5/detail.html#PairedTwoGroupDifference
where you have EVs to model each of the subject means across the two sessions. Then you have alongside those an EV to model your behavioural data. 

FLAME1 has most of the key benefits associated with FLAME2 with respect to using variances from the first level, it just trades off a bit of accuracy in the interest of speed - but is perfectly adequate for most purposes.

Apologies if I have misunderstood.

Cheers, Mark.

----
Dr Mark Woolrich
EPSRC Advanced Research Fellow University Research Lecturer

Oxford University Centre for Functional MRI of the Brain (FMRIB),
John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.

Tel: (+44)1865-222782 Homepage: http://www.fmrib.ox.ac.uk/~woolrich




On 10 Jul 2007, at 19:48, James N. Porter wrote:


I would like to know how to properly account for within-pair variance correlation in FEAT in a twin design. We have measured a continuous variable for all subjects that we are using as a regressor in our fMRI analysis, but we recognize that this variable may not have error that is independent of the twin-pair sampling. In our behavioral analysis in STATA, we can easily implement a design that cluster/nests the twin pairs to obtain robust standard errors. For the neuroimaging analysis, the path is not so clear. I have the following questions:


1) We believe that FLAME 2's full MCMC resampling would automatically produce robust standard errors in this case, but we would like to save time by just running FLAME 1. Does the Metropolis Hastings sampling procedure also result in robust standard errors in this case?


2) At the higher-level, would indicating separate Group membership in FEAT's GLM setup (i.e. Inputs 1&2=Group 1, Inputs 2&3=Group 2, etc) be the same as clustering twin pairs?