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Dear Friend: I'm wondering if my following understanding of mean image is correct. Assume I have two subjects, and there are A, B, C three points in adjacent brain areas. B is between A and C. If one subject show activation in A and deactivation in C, while the other subject shows activation in C and deactivation in A, the mean image of the two subjects may show neither activation nor deactivation. If one subject show highest activation in A, less activation in B, and no activation in C, and the other subject show highest activation in C, less activation in B, and no activation in A. The mean image may show activation in B but not in A and C. Any comments are appreciated Jiansong