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Many thanks Ian,

Have you noticed that Tang et al’s meta-analysis seems to be the only one 
which used statistical analysis (Egger’s regression model) to detect 
publication bias?

Tang et al’s thus showed that the missing studies were located at the left 
of the funnel plot; consistent with the general observation that studies 
with less optimistic estimation of diagnostic performance are less likely to 
be published.

Best regards,

Joseph

>From: Ian Barlow <[log in to unmask]>
>Reply-To: Ian Barlow <[log in to unmask]>
>To: [log in to unmask]
>Subject: Re: Procalcitonin
>Date: Mon, 9 Jul 2007 12:36:22 +0100
>
>Dear colleagues,
>
>Is procalcitonin better than CRP?
>
>Thanks to Joseph and David for these references.
>
>I attach a short summary of these reviews and also include my 
>interpretation of things as they are now.
>
>Best wishes
>
>Ian Barlow
>Scunthorpe
>UK
>
>
>
>
>
>-----Original Message-----
>From: Clinical biochemistry discussion list
>[mailto:[log in to unmask]]On Behalf Of Joseph WATINE
>Sent: 20 June 2007 09:19
>To: [log in to unmask]
>Subject: Re: Procalcitonin
>
>
>in addition to these 2 articles, at least 5 other systematic reviews or
>meta-analysis have been published on the subject. Apparently some of the
>conclusions of these 7 articles seem to contradict with each other. Please
>feel free to critically summarize these conclusions for us:
>
>1) Gattas DJ, Cook DJ. Procalcitonin as a diagnostic test for sepsis: 
>health
>technology assessment in the ICU. J Crit Care. 2003 Mar;18(1):52-8.
>2) Sponholz C, Sakr Y, Reinhart K, Brunkhorst F. Diagnostic value and
>prognostic implications of serum procalcitonin after cardiac surgery: a
>systematic review of the literature. Crit Care. 2006 Oct 13;10(5):R145
>3) van Rossum AM, Wulkan RW, Oudesluys-Murphy AM. Procalcitonin as an early
>marker of infection in neonates and children. Lancet Infect Dis. 2004
>Oct;4(10):620-30.
>4) Shafiq N, Malhotra S, Bhasin DK, Rana S, Siddhu S, Pandhi P. Estimating
>the diagnostic accuracy of procalcitonin as a marker of the severity of
>acute pancreatitis: a meta-analytic approach. JOP. 2005 May 10;6(3):231-7.
>5) Jones AE, Fiechtl JF, Brown MD, Ballew JJ, Kline JA. Procalcitonin Test
>in the Diagnosis of Bacteremia: A Meta-analysis. Ann Emerg Med. 2006 Dec 8;
>[Epub ahead of print]
>
>Dr Joseph Watine, PH, AIHP, PharmD, AAHU, EurClinChem
>Laboratoire de Biologie Polyvalente
>Centre Hospitalier Général
>12027 Rodez Cedex 9
>France
>
>
> >From: David Gaze <[log in to unmask]>
> >Reply-To: David Gaze <[log in to unmask]>
> >To: [log in to unmask]
> >Subject: Procalcitonin
> >Date: Wed, 20 Jun 2007 07:39:19 +0100
> >
> >
> >
> >Ian,
> >
> >
> >
> >See:
> >
> >1.	Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret G-Y.
> >Procalcitonin as a diagnostic test for sepsis in critically ill adults
> >and after surgery or trauma: a systematic review and meta-analysis. Crit
> >Care Med 2006; 34: 1996-2003
> >
> >
> >
> >Regards
> >
> >
> >
> >
> >
> >
> >
> >David C Gaze
> >
> >Cardiac Research Scientist
> >
> >Chemical Pathology
> >
> >Jenner Wing, Level 2
> >
> >St George's Healthcare NHS Trust
> >
> >London, SW17 0QT
> >
> >Tel:       +44 (0)20 8725 5878
> >
> >Fax:      +44 (0)20 8682 0744
> >
> >Email:   [log in to unmask]
> ><mailto:[log in to unmask]>
> >
> >P Please consider the environment before printing this e-mail.
> >
> >-----Original Message-----
> >From: Clinical biochemistry discussion list
> >[mailto:[log in to unmask]] On Behalf Of Ian Barlow
> >Sent: 19 June 2007 17:30
> >To: [log in to unmask]
> >Subject: Procalcitonin
> >
> >
> >
> >Dear colleagues,
> >
> >I am aware that this topic was discussed about year ago but I wondered
> >what the current status was.
> >
> >Is anyone using this routinely? What platform? What is your experience?
> >
> >Is anyone aware of any recent systematic reviews or meta analysis?
> >I am aware of the one in 2004:-
> >Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J. Serum
> >procalcitonin
> >and C-reactive protein levels as markers of bacterial infection: a
> >systematic review and meta-analysis. Clin Infect Dis. 2004 Jul
> >15;39(2):206-17.
> >
> >Many thanks
> >
> >Best wishes
> >Ian Barlow
> >Scunthorpe
> >UK

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