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Serum Amyloid A (SAA) is an acute phase protein (an apolipoprotein of HDL) that behaves in a manner similar to CRP. The serum concentrations of SAA do not predict the extent of protein deposition into amyloid fibrils in inflammation-asociated amyloid (AA-form or secondary amyloid). There twenty-some different diseases that involve some form of protein deposition into amyloid fibrils, that involve different proteins. Several of these disorders can manifest with some symptoms of neuropathies. It has been about 15 years since I dabbled in this area of research, but I don't see how a SAA level could be related to decisions for nerve biopsy....and I would be inclined to suggest substituting a CRP level for the SAA request. regards, Andrew Dr. A. Lyon, Univ. Calgary. in reply to: ----- Original Message ----- From: "O'Connor John (Royal Devon and Exeter Foundation Trust)" <[log in to unmask]> Date: Monday, July 2, 2007 3:33 am Subject: Serum Amyloid A ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/