Print

Print


Dear Sein,

You can either concatenate the data or analyse the sessions separately and then perform an appropriate second level test (see previous postings on this topic today).  If you do concatenate, the procedure outlined by Darren an earlier today should be perfectly sufficient in most cases.  If you have extreme differences in session-wise variance, some sort of normalisation (like z-the transformation) could be considered, but I am not aware of any study that has looked into the pros, cons and limits of this.

Best wishes,
Klaas



At 17:31 12/06/2007, you wrote:
 
Dear Klaas Enno,
 
Some questions to DCM (multiple subjects)
 
Design:
E.g.: 1 Subject, 5 Sessions with randomized stimuli
 
For DCM (audit SPM list):
  1. concatenate the 5 sessions
  2. account for session transitions with covariate of no interest
  3. identify ROI’s
  4. run DCM
 
à in SPM99 the data was z-transformed before concatenation
à this possibility was disabled because concatenation is not statistically solid
 
Should I concatenate? 
Should I z-transform the sessions?
 
Variant 2:
Is there no possibility to concatenate the VOI’s (i.e. the response variables Y.y & Y.XO)?
N.B.: The input from SPM.mat seems to be confined to the onsets (stick-functions)
 
 
Cheers,
Sein
 
 
 
 
 
-------------------------------------------------------
[work]
Hr. Sein Schmidt
Vision & Motor Systems Group
(Dept. of Neurology)
Charité Campus Mitte
Charitéplatz 1
10117  Berlin, Germany
 
sein.schmidt-at-charite.de
tel.: ++49 (30) 450.560.045
fax: ++49 (30) 450.560.952



http://www.berlin-neuroimaging-center.de/groups/vision/index_html
 
CONFIDENTIALITY NOTICE: This email contains information from the sender
that may be CONFIDENTIAL, LEGALLY PRIVILEGED, PROPRIETARY or otherwise protected from disclosure. This email is intended for use only by the person or entity to whom it is addressed. If you are not the intended recipient, any use, disclosure, copying, distribution, printing, or any action taken in reliance on the contents of this email, is strictly prohibited. If you received this email in error, please contact the sending party by replying in an email to the sender, delete the email from your computer system and shred any paper copies of the email you printed.
 

_____________________________________
Klaas Enno Stephan, MD PhD
Senior Research Fellow, IoN
Wellcome Trust Centre for Neuroimaging
Institute of Neurology (IoN)
12 Queen Square, WC1N 3BG, London, UK
phone: +44-207-8337481
fax: +44-207-8131420
web: http://www.fil.ion.ucl.ac.uk/~kstephan/