Hi Franck, I haven't found a hint in your e-mail which image volume you specify as reference image. But correction for eddy currents distortions will probably fail if you choose the b0-volume due to the high CSF signal which is not present in b1000-images. Regards, Jochen >>> Lamberton Franck <[log in to unmask]> 10.05.07 11.13 Uhr >>> Hi, I worked with DTI a few weeks ago and used FDT in order to compute FA (last version of FSL running on Linux FC4). Recently, I acquired a set of diffusion weigthed images on a subject with minimal head movement (head control) : 40 slices 1 b=0 s/mm2 + 32 different encoding directions at b=1000 s/mm2 resolution = 2x2x2 mm3 Using the 'Movie mode' of fslview shows that very little distortion occured between successive acquisitions (they seem to be related to eddy-currents). After applying 'eddy_correct', significant geometrical distortion appeared in the se ries that were not present in the first place. I also used avwmaths++ command with the option -Tstd in order to compute the standard deviation of the series. Signifi cant geometrical distortion introduced by eddy_correct induced high std values all arround the brain. I edited the script 'eddy_correct' in order to test different options of FLIRT, cost function (-searchcost) and no ang ular research limitation (-nosearch). In all cases, spurious geometrical distortions remain the same after applying the modified 'eddy_correct'. I also used the option "-interp nearestneighbour" in order to better compare uncorrected and corrected series (less blurring). To do this, I used 'avwmaths++' with '-Tstd' option in order to compute the std volume of only corrected diffusion weighetd volumes. After correction, greater values appear at the periphery of the brain. Does anyone have already seen a similar effect of 'eddy_correct' ? What about using -refweight or -inweight of FLIRT ? How can I use this two options ? Thanks for any response Franck