Dear List members,
 
I'd appreciate your help. I've had a letter from a GP complaining about the variation in PSA results for a patient; a 66 year old man whose PSA on Beckman Hybritech was 4.9 and from Abbott Architect was 6.5 on the same day, but not the same sample. His previous results over the last 2.5 years were 6.0 (Bayer),5.8 (Bayer), 5.7 (Bayer) then a change to Hybritech gave this result of 4.9.
 
What do I tell the GP? I know the Abbott assay runs higher than the Hybritech. How much within person variation is there for PSA?
 
Many thanks
 
Helen Smith
 
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