Dear Teri,

Thank you – I have read the paper (HBM 5(2) 133-6 "Testing for anatomically specified regional effects") and your technique makes much more sense to me than using the SVC tool. With your method, a priori regions can be examined, even with the confounds of limited spatial resolution, imperfect normalization, and group data issues. Using the SVC tool, you can just about pick your own p value. But, I can’t quite figure out how to use the equation. Has there been discussion about this previously? I realize this is an older paper... I did look at the archives but nothing really popped out.

To use this approach in a practical sense, you simply use the uncorrected
cluster-level P-value in the results table. If this P-value is less than 0.05,
for the cluster nearest your a priori location, the cluster can be declared significant.

The inference is very simple and can be useful when you know roughly where
your activation of interest lies.

I hope this helps - Karl