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Dear Teri, >Thank you – I have read the paper (HBM 5(2) >133-6 "Testing for anatomically specified >regional effects") and your technique makes much >more sense to me than using the SVC tool. With >your method, a priori regions can be >examined, even with the confounds of limited >spatial resolution, imperfect normalization, >and group data issues. Using the SVC tool, you >can just about pick your own p value. But, I >can’t quite figure out how to use the >equation. Has there been discussion about this >previously? I realize this is an older >paper... I did look at the archives but nothing really popped out. To use this approach in a practical sense, you simply use the uncorrected cluster-level P-value in the results table. If this P-value is less than 0.05, for the cluster nearest your a priori location, the cluster can be declared significant. The inference is very simple and can be useful when you know roughly where your activation of interest lies. I hope this helps - Karl