Dear Maxwell, >I am trying to do a longitudinal study using repeated measures ie >perform fmri study in 12 patients at 2wks, 4 wks, 6 wks, 8 wks, 12wks, >6 months and 1 year. I will collect motor recovry score(number >ranging from 1-100) at each >of these time points. I am interested in correlations between fmri >activation and the motor score. I would like to assess if individual >activations change with time and whether these changes correlate with >motor score. What is the best way to analyze the data at individual >level and group level. I would use a three-stage analysis; at the between-scan, between- repetition and between-subject levels. This entails estimating the session-specific motor activations for each repetition and subject. Then take the contrast for motor-related responses to a second level to test for within-subject effects of time and or recovery; note these will be confounded, so do one at a time. Use age etc as a confound. Finally, take the contrasts testing for an effect of time (or recovery) to a third between-subject level, using a one-sample t-test. I hope this helps - Karl