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Hi Wendy, I have no expertise in chemistry, but when I was 13 weeks pregnant had a threatened miscarriage and was told to use paracetamol from then on for headaches etc for the duration of the pregnancy and NOT aspirin. I was not told why and at that stage I didn't ask many questions. Is there any way this work could continue without specifically her involvement? Roberta ----- Original Message ----- From: "Wendy Jones" <[log in to unmask]> To: <[log in to unmask]> Sent: Thursday, April 19, 2007 5:05 PM Subject: [OCC-HEALTH] Pregnancy risk assessment - aspirin-like substances >I have been asked to advise on a pregnancy risk assessment for someone in >our chemistry department. The work is based on samples of Aspirin like >compounds, specifically those found in treatments for ulcerative colitis >such as sulphasalazine, mesalazine and Balsalazide; and samples of Ferric >chloride. The work will last about 5 weeks, and the pregnancy is half way >through. > > Having checked the BNF, aspirin is not restricted in pregnancy, > sulphasalazine and mesalazine are to be 'used with caution' and > balsalazide is to be avoided. The concentrations in the experiments will > be low - equivalent to the levels of aspirin -like compounds likely to be > found on the urine of someone taking therapeutic doses of drugs for > inflammatory bowel disease. On this basis my inclination is to let the > work go ahead. > > I would appreciate any comments from someone with greater chemical > expertise than me if you think I'm missing something and should be saying > no. Incidentally they have also asked about using Mercuric Chloride in > very small quantities and I am going to be advising against this as it has > known reproductive effects in addition to its general high level of > toxicity. > > Regards > Wendy > > > Wendy Jones > Occupational Health Adviser > Loughborough University > 01509 222851 > ~~~~~~~~~~~~~~~ > Please remove this footer before replying. > > ARCHIVES > http://www.jiscmail.ac.uk/lists/occ-health.html > > FORTHCOMING CONFERENCES AND EDUCATIONAL EVENTS: > http://www.jiscmail.ac.uk/cgi-bin/filearea.cgi?LMGT1=OCC-HEALTH > > OCCUPATIONAL HEALTH JOBS > http://OHJobs.drmaze.net > > OCCUPATIONAL HEALTH NURSING COURSES > http://home.wlv.ac.uk/~in6232/aohne/ > ~~~~~~~~~~~~~~~ Please remove this footer before replying. ARCHIVES http://www.jiscmail.ac.uk/lists/occ-health.html FORTHCOMING CONFERENCES AND EDUCATIONAL EVENTS: http://www.jiscmail.ac.uk/cgi-bin/filearea.cgi?LMGT1=OCC-HEALTH OCCUPATIONAL HEALTH JOBS http://OHJobs.drmaze.net OCCUPATIONAL HEALTH NURSING COURSES http://home.wlv.ac.uk/~in6232/aohne/