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Dear Matt, A very good evening from the East of England. You might find this paper of some relevance regarding your above posting. I found Table 1 quite interesting. Factors that can affect the external validity of Randomised controlled trials. Full text @ http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1488890&blobtype=pdf Warm regards & very best wishes, Badri Dr P Badrinath MD BS M.Phil MPH FFPH PhD (Cantab) Consultant in Public Health Medicine & Affiliated Clinical Lecturer Suffolk PCT & University of Cambridge Rushbrook house, Paper mill lane, Bramford, Ipswich, IP8 4DE, Suffolk, UK http://myprofile.cos.com/badrishanthi