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Dear Francesco, You can do it in SPM. With the GUI, click on display. In the graphics window click where you want the origin to be. The 3 values that pop up when you click on a coordinate are the x, y, z of the point relative to the current origin. Change the x, y, and z in the boxes below to the negative of the values and click on re-orient image. Choose the same image and click done. Origin should then be fine. Best Wishes, Geoffrey Tan francesco de Bertoldi wrote: > Dear SPM users, > I want to set the anterior commissure as the origin of the spatial > coordinates for the normalization algorithm with SPM5. > I've tried with mricro (version 1.39 build 5) to use the function > "save header" but when i open the saved image, his origin of voxel is > the same as the original image. Is there a way to do it with this > versions of the programs? > Any help would be appreciated. > Thank you > Francesco > >