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Hi All, I was wondering how to properly define the stereochemistry for a new ligand in sketcher. In the sketcher interface there are three columns after the stereochem sign option. I would assume that the order in which you enter the chiral neighbors would effect the sign that you choose for your stereochemistry. Does any one know how sketcher reads these three columns to determine the stereochemsitry? Thanks in advance for your help. Cheers, Vu