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Hello David I'm not sure it qualifies as a "strategy", but I spent time looking into a case of atypical reaction to alcohol (with help from mailbase members) in 2000. Remarkably, I found the file within a minute of your email....! Things to think about: - psychosocial history - ethnicity (flush reaction v.common in Japanese/Chinese/Koreans) - is it a flushing reaction or other type of effect? - nature of effect - blood glucose at the time, BP, heart rate - also some forms of adverse reaction to EtOH are associated with lymphoma (Hodgkins) (localised pain in lymph nodes) Type of alcohol - is it all forms, or specific forms (i.e. ? Other components/congeners and not EtOH itself.) Does vodka cause reaction? Drugs - described in people on chlorpropamide/other hypoglycaemics You can get ADH and ALDH genotype done - ask me for contact names (from 2000 so may not still be valid) Ref (now rather old) Crabb DW J Lab Clin Med 1993 122: 234-40 Hope that's some help Mike -----Original Message----- From: David Burgess [mailto:[log in to unmask]] Sent: 13 March 2007 09:04 To: [log in to unmask] Subject: EtOH Does anyone have a strategy for the investigation of an otherwise healthy individual who suffers from an adverse reaction to trivial quantities of ethanol? Regards, David. ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ This electronic message may contain information from Shrewsbury and Telford Hospital NHS Trust which may be privileged or confidential. The information is intended to be for the use of the individual(s) or entity named above. If you are not the intended recipient be aware that any disclosure, copying, distribution or use of the contents of this information is prohibited. If you have received this electronic message in error, please notify us by telephone or email (to the numbers or address above) immediately. ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/