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<<FullFactorial.jpg>> <<FlexibleFactorial.jpg>> Dear SPM5 experts: We are trying to set up Repeated Measure ANOVA on SPM5 with full or missing data 1. Flexible Factorial with full data I ran a RMANOVA with PET data over 3 time points using a flexible factorial design. This was done with two factors (repetition, subject). The scans were entered for each of 10 subjects with a condition of 1 2 3 and without interaction between factors. The design matrix looks right according to spm5 manual (see jpg file). I used a T contrast of (2 -1 -1) or (-2 1 1) to examine the decreased or increased main effect over the 3 time points. 2. Full Factorial with full data I tried to replicate the analysis above with full factorial model. I specify two factors (repetition, 3 levels; subject 1 level). For each of 3 cells I enter levels (1 1) / (2 1) / (3 1) with scans from all subjects in the same order. The design matrix (see attached jpg file) is different but seems to indicate interaction between repetition and subject. However the results appear to be very similar with the same contrast. 3. Full Factorial with missing data According to the emails on the list and other documentation it seems possible to use Full Factorial design in spm5 to handle RMANOVA with missing data. This often happens in a longitudinal study to follow disease progression or treatment outcome. However, it is unclear how this can be done with the way the scans are entered. Dropping scans of the last 2 subjects at time 3 seem to work but I am not sure whether that is correct in spm5 implementation. Perhaps some of you have already figured out a clever specification of cells. Would you please confirm whether my setup is correct in analyses 1 & 2. We would be grateful to get any input on how to enter missing data in a general way. Lastly, please advise whether there is any potential problem if snr* scans are generated from spm99. Many thanks for your help on our way to SPM5. Best regards, Yilong Ma Associate Professor Departments of Neurology and Medicine New York University School of Medicine Room 224 350 Community Drive Manhasset, NY 11030 Tel: 516-562-1057 (office) Fax: 516-562-1008 (office) Email: [log in to unmask] --------------------------------------------------------------------------------- The information contained in this electronic e-mail transmission and any attachments are intended only for the use of the individual or entity to whom or to which it is addressed, and may contain information that is privileged, confidential and exempt from disclosure under applicable law. If the reader of this communication is not the intended recipient, or the employee or agent responsible for delivering this communication to the intended recipient, you are hereby notified that any dissemination, distribution, copying or disclosure of this communication and any attachment is strictly prohibited. If you have received this transmission in error, please notify the sender immediately by telephone and electronic mail, and delete the original communication and any attachment from any computer, server or other electronic recording or storage device or medium. Receipt by anyone other than the intended recipient is not a waiver of any attorney-client, physician-patient or other privilege. Thank you.