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Dear All, This is your last chance to register for Stephen Senn's course on 'Statistical Issues in Designing and Analysing Clinical Trials'. There are only a few places left so get in contact asap if you don't want to miss out. Date: Monday 26th February 2007 Venue: University of Glasgow Registration: Please contact Brad Payne on 0115 8488410 or email [log in to unmask] A One-Day Course at the University of Glasgow By Stephen Senn. Synopsis Based on Stephen Senn's critically acclaimed book "Statistical Issues in Drug Development", this course is particularly suitable for statisticians who wish to obtain a concise overview of controversies they may encounter in designing and analysing clinical trials. It is also suitable for life scientists who wish to deepen their appreciation of important statistical concepts and issues. The emphasis of the course will be on "why" rather than "how" and on philosophy rather than calculation, although recommendations will be made as to how trials should be analysed. Mathematical technicalities will be avoided but problems and issues will be frankly explored. Biopic Stephen Senn is Professor of Statistics at the University of Glasgow and was previously Professor of Pharmaceutical and Health Statistics at University College London. He worked for many years in the Swiss pharmaceutical industry and consults regularly in Europe and America on statistical issues in drug development. He is the author of Cross-over Trials in Clinical Research (1993, 2nd edition 2002), Statistical Issues in Drug Development, 1997 and Dicing with Death (2003). He is the winner of the George C Challis award for biostatistics of the University of Florida (2001) and the PSI award for the most interesting speaker in 25 years of conferences (2002). Cost: £70 (for university staff and students) includes tea, coffee, lunch and course materials (discounts available for participants from same university/college - £120 for two, £165 for three) £120 (for non-academics) Registration: See below (Please state if you have any special dietary requirements) Programme (provisional) 10.00-10.15 Registration and Welcome 10.15-11.15 Session 1: THE PHILOSOPHY OF CLINICAL TRIALS * Causality: subsequence and consequence * The man who woke up Immanuel Kant. Hume's problem of induction. * Controlled inference * Regression to the mean: things aint what they seem. * Randomisation. Ration roulette * Blinding. The misunderstood placebo * Measuring effects: The dangers of over-interpretation 11.15-11.30 Coffee Break 11.30-12.30 Session 2: ALLOCATING PATIENTS TO TREATMENT * Randomisation * Placebo run-ins * Minimisation * Ethical problems * Bandit designs * Cut-off designs * Sequential designs 12.30-13.30 Lunch 13.30-14.30 Session 3: BASELINES AND COVARIATE INFORMATION * Baseline balance * Adjusting for baselines * Multiple baselines * Analysis of covariance * Late baselines 14.30 - 14.45 Tea Break 14.45 - 15.45 Session 4: MEASUREMENT OF TREATMENT EFFECTS * Additivity * Individual response * Trend effects * Dichotomising continuous variables * Surrogate endpoints 15.45 - 16.00 Discussion and Close This email is intended solely for the addressee. It may contain private and confidential information. If you are not the intended addressee, please take no action based on it nor show a copy to anyone. In this case, please reply to this email to highlight the error. Opinions and information in this email that do not relate to the official business of Nottingham Trent University shall be understood as neither given nor endorsed by the University. Nottingham Trent University has taken steps to ensure that this email and any attachments are virus-free, but we do advise that the recipient should check that the email and its attachments are actually virus free. This is in keeping with good computing practice.