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Hello Leighton, Thank you for the reply. 1) One can test spatial normalization results buy correlating the surface boundaries of the registered image with template brain, i.e looking for a match in the dimensions as well as the anterior portion and the posterior portion in all the three orientations, or if I have fiducial markers in the SPECT image then check that after spatial normalization the fiducial markers are on the brain boundaries and not anywhere else. SO when I say "better" I check all these parameters and then decide the result. 2) your suggestion of creating a template is good, but even to create a template you have to get all the images in Talairach atlas, which you can do through spatial normalization, so spatial normalization is a preliminary step to create template and not the later step. Not a problem to ask questions as we are all learning. Abhinay On 1/11/07, Barnden, Leighton (NWAHS) <[log in to unmask]> wrote: > > Hi there Abhinay, > What do you mean by 'better'? I wouldn't have expected the difference > between the SPECT and PET templates to significantly affect the spatial > normalisation of low-resolution I-123 SPECT. > Is the distribution of your I-123 ligand very different to the FDG PET or > HMPAO SPECT templates? If so, you may benefit from generating your own > template - if you have enough I-123 scans. > Sorry to return more questions than answers. > Leighton > > *Leighton Barnden PhD* > *Medical Scientist* > *Nuclear Medicine, The Queen Elizabeth Hospital* > *Woodville Road, Woodville* > *SA 5011, Australia* > *ph. +61 8 8222 6438* > > > -----Original Message----- > *From:* SPM (Statistical Parametric Mapping) [mailto:[log in to unmask]] *On > Behalf Of *Abhinay Joshi > *Sent:* Thursday, 11 January 2007 4:57 PM > *To:* [log in to unmask] > *Subject:* [SPM] Spatial Normalization > > Hello Everyone, > > Issue:-Spatially normalization of the SPECT images of radio-ligand I-123 > in AD patient and HC subject. > Results:The result of Spatial normalization using PET template is better > than using the SPECT template. > Reasons that I think:-SPECT images on which I am working on are not clear > and very hazy and the SPECT template gives a clear shape > of the brain as compared to PET template, so in my case PET template > suited the better...I can be wrong!! > > Could any one please provide any other probable reasons for it? > > Thank you all in advance. > > Sincerely, > > > > -- > Abhinay D. Joshi > UT Southwestern > E06.122 MC 9061 > Dallas, TX 75390 > P -214-648-9265 > > Biomedical Engineer > Avid Radiopharmaceuticals > 3624 Market Street > 5th floor, > Philadelphia, PA 19104 > > -- Abhinay D. Joshi UT Southwestern E06.122 MC 9061 Dallas, TX 75390 P -214-648-9265 Biomedical Engineer Avid Radiopharmaceuticals 3624 Market Street, 5th floor Philadelphia, PA 19104