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Hi Phil, You're right that Christian Gaser's VBM2 toolbox for SPM2 http://dbm.neuro.uni-jena.de/vbm/vbm2-for-spm2/) just does GM-to-GM optimised normalisation. It's relatively easy to change the code to do WM-to-WM if you want to try that. If what you really want is unified segmentation and normalisation that is simultaneously "optimised" for all three tissue classes, then maybe you want SPM5. Best, Ged. Phil Greer wrote: > > Does anyone know of any posters/papers/studies looking at the > normalization methods for white matter vbm? I have been looking > at ways to get more accurate assessments of white mater > changes and have noticed that the vmb optimized toolbox does > not currently offer the ability to alter how the images are normalized. > They are simply normalized via gm to gm, at least in spm2. > Any help would be appreciated. > > -Phil Greer, >