A biochemist friend asked for examples of cases were a protein was

co-crystallized with or soaked in a ligand that bound in the wrong place

- say, because the ligand used wasn't quite the right one or because

other important ligands were absent.

I'm sure such examples are out there, especially when soaks were done at

high concentrations, but I'm having trouble thinking of concrete

examples.

Help?

thanks,

Phoebe Rice

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Phoebe A. Rice

Assoc. Prof., Dept. of Biochemistry & Molecular Biology The University

of Chicago phone 773 834 1723 fax 773 702 0439

http://bmb.bsd.uchicago.edu/index.html

http://www.nasa.gov/mission_pages/cassini/multimedia/pia06064.html