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Dear All, If you knew which cycteines were engaged in disulfide links, you could set that at the beginning. You would then be free to decide later exactly which cysteines were linked together. At least that is the way it is recommended in the data model. How it works in current Analysis Tim would know better than I. Yours, Rasmus --------------------------------------------------------------------------- Dr. Rasmus H. Fogh Email: [log in to unmask] Dept. of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK. FAX (01223)766002 On Fri, 10 Nov 2006, Tim Stevens wrote: > > Is there a way of editing an existing molecule template to introduce > > links between cysteines to form disulfides? I know this can be done when > > first creating the new molecule but what about at a later stage? > > Not yet, but in the next version you can 'unlock' a molecule so that you > can change the sequence elements (linking, descriptor & CCP code) and set > an intra molecule link. > > Adding or removing residues, and the ability to define intra chain > links will appear later. > > > I appreciate that modifying the covalent state of a molecule at a later > > stage of a project may not be ideal but it may be necessary in the case > > of disulfides if these are not known from the onset. > > Agreed. > > In the mean time, if you're desperate and don't mind faffing, you can make > new molecules and chains and transfer chain assignments. > > T. > > ------------------------------------------------------------------------------- > Dr Tim Stevens Email: [log in to unmask] > Department of Biochemistry [log in to unmask] > University of Cambridge Phone: +44 1223 766018 (office) > 80 Tennis Court Road +44 7816 338275 (mobile) > Old Addenbrooke's Site +44 1223 364613 (home) > Cambridge CB2 1GA WWWeb: http://www.bio.cam.ac.uk/~tjs23 > United Kingdom http://www.pantonia.co.uk > ------------------------------------------------------------------------------- > ------ +NH3CH(CH(CH3)OH)C(O)NHCH(CH(CH3)CH2CH3)C(O)NHCH(CH2CH2SCH3)CO2- ------- > ------------------------------------------------------------------------------- >