Dear all,

 

I am trying to write an in service on the causes of night pain.  I have been told as a junior that chemicals (inflammatory mediators?) settle onto nerve endings at night and this is the basis of pain. 

 

Is there any evidence to support this?  I have done a pubmed search and yielded not a lot (using search terms: "night pain", inflamatory and chemical) any help would be greatfully recieved.

 

Thanks,

 

John