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Hi Juergen, Seems I spoke too soon... Juergen Haenggi wrote: > (under the Custom option) there is following statement: > > The original data are derived from 452 T1-weighted > scans, which were aligned with an atlas space, > corrected for scan inhomogeneities, and classified > into grey matter, white matter and cerebrospinal > fluid. These data were then affine registered to the > MNI space and downsampled to 2mm resolution. Right, I was just thinking about the template for some reason... So I am pretty certain that the spm5/templates/T1.nii is the MNI/ICBM152 template, not the 452 version, but... The TPMs in SPM5 might well come from the ICBM452 rather than 152, sorry about my confusion here. Since the SPM5 TPMs are quite sharp, I'm guessing that they are the 5th order polynomial warped version that you spoke of (but it's just a guess, I should really wait for JA to reply...) > Do you have any idea what the difference between the > a priori maps located in the tpm and that located > in the apriori folder is? The apriori folder contains the much smoother SPM2 priors. What I don't know is whether these are smoother due to using the affine-registered ICBM452 version, or maybe the 152 version, or whether they were simply Gaussian smoothed versions of the sharper SPM5 TPMs. Hopefully John Ashburner will clear up this mess that I have gotten us into... ;-) Ged.