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ika16 wrote: > If I get 10 x 2 design matrix, how can I put it into SPM? > Need Matlab code or anything else? It's easier to let SPM create the design matrix based on the model that you specify with the GUI. Otherwise, I think you have to manually set up the structures in the SPM.mat (see e.g. spm_config_factorial_design.m). I haven't found an easy way to manually set up a simple case for spm_spm to estimate -- hopefully someone will correct me here if I'm missing something. If you do just want a simple Ordinary Least Squares estimation from a specified design matrix, then you could probably code it up yourself fairly quickly, using the standard expressions (e.g. beta = (X'*X)\X'*y etc) and SPM functions to read the image data. > And a covariate vector always has to be one column vector? Yes, a column is a covariate. > If a covariate is a column of the design matrix, > how can I put two columns of covariates into SPM? > Have twice for "New Covariate"? Sounds good to me! Best, Ged.