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Dear Witaya, >The SPGR has 120 slices, and T2 has 20 slices (each slice is 256* 256). After I do the >coregistration from T2 to SPGR in SPM2, I read entire image volumes. However, the dimension of >SPGR image matrix is still 256*256*120, and the dimension of T2 image is still 256*256*20. >Then I still can't find the 'One to One' relationship between the SPGR and T2 volume matrix. > >Inadvertently, you might have fogotten to click 'Coregister & Reslice'. >If you do so, rT2.img should have the same dimension with SPGR.img. >Cheers, Thanks a lot for your quick reply and the convenient method!!! It works really very well. Happy valentines Day! Lily