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Dear Punervasu Vyas, you can calculate ADCs with the diffusion toolbox. Use (Re)set DTI information to store your gradient directions and b values in your images (also for your b0 image - use b value 0 and gradient [0 0 0]) for that. Note, that the gradient vectors given in your bvecs file do not have unit length. The toolbox will scale your b value with the length of your gradient vector, which might not be what you want. If there is anything unexpected happening while you use the toolbox, please let me know via the sourceforge help/bug tracking web site. Cheers, Volkmar On Mon, 21 Aug 2006, Punervasu Vyas wrote: > Dear All > I would like to know the way to evaluate the ADC values from diffusion > weighted images in SPM5. I need to check the reproducibility and accuracy of > apparent diffusion coefficient (ADC) > I have the diffusion toolbox needed for diffusion calculations. I have a set > of DW images acquired on a Siemens 1.5T scanner. The gradient direction file > is attached. Is there any thing else required. Anyhelp in this would be > useful. > Thanking you > Punervasu Vyas > -- Volkmar Glauche - Department of Neurology [log in to unmask] Universitaetsklinikum Freiburg Phone 49(0)761-270-5331 Breisacher Str. 64 Fax 49(0)761-270-5416 79106 Freiburg