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POST-GRADUATE BIOINFORMATICIAN/STATISTICAL GENETICIST Wellcome Trust Centre for Human Genetics, University of Oxford ACADEMIC-RELATED RESEARCH STAFF GRADE IB: £20,044 - £25,565 MolPage (Molecular Phenotyping to Accelerate Genetic Epidemiology) is a large EU-funded research programme aimed at developing technological and statistical tools required to exploit information from biological samples that will increasingly become available in future epidemiological studies. The development of these tools in MolPage is aimed specifically at biomarker discovery for metabolic disorders related to diabetes and cardiovascular disease. However, the tools developed will be of much wider use in the identification of biomarkers that predict many differents types of disease, determine risk or determine response to therapy. Professor Cardon's statistical genetics group at The Wellcome Trust Centre for Human Genetics leads the MolPage module aimed at assessing data variability through the use of twin models. The type of biological data to be analysed will be of genomic, transcriptomic (micro-array gene expression), metabonomic, proteomic and peptidomic (NMR/MS) nature. Professor Cardon and Dr Zondervan now require a statistical geneticist/bioinformatician to conduct statistical analyses of the emerging data. A graduate (preferably post-graduate) degree in statistics, bioinformatics, mathematical biology, or genetic epidemiology/statistical genetics is essential. The successful candidate should have experience in applied computational methods in statistical genetics/genetic epidemiology, and experience with analysis of transcriptomic, metabonomic or proteomic data is highly desirable. Experience in variance components analysis or allied methods employed in twin studies would also be of distinct advantage. The work will involve close collaboration with other investigators in Molpage and therefore communication skills and ability to work effectively in a team will be important. The position is available for 2.5 years in the first instance and funded by Molpage. A detailed job description quoting reference H5-06-007-KZ is available from the Personnel Administrator (tel: 01865 287508, email [log in to unmask]) or by going to: http://www.well.ox.ac.uk/vacancies/Molpage%20job%20description-KZ.doc <http://www.well.ox.ac.uk/vacancies/Molpage%20job%20description-KZ.doc>. To apply please send your curriculum vitae with a letter of application and the names and addresses of two referees to the Personnel Administrator, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN or by email to [log in to unmask] or fax to 01865 287516. Please quote the above reference number. The closing date for applications is 31 March 2006.