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Prof. Tim
Reynolds,
Queen's Hospital,
Belvedere Rd,
Burton-on-Trent,
Staffordshire,
DE13 0RB
work tel: 01283 511511 ext.
4035
work
fax: 01283 593064
work email: [log in to unmask]
home email:
[log in to unmask]
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-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Roger Ekins
Sent: 15 November 2006 13:24
To: [log in to unmask]
Subject: Re: Antibodies in the greenhouseInteresting and potentially valuable in situations when "very large-scale manufacturing of antibodies" (as in the case of pandemics) is required - but first you must identify your high affinity monoclonal Ab. Not always that easy!.Roger EkinsUCLHiI just came across this review in Chemistry world (from a paper in ProcNatAcadSci), which describes the production of gram quantities of IgG antibodies from tobacco plant leaves.This may be of interest to two groups; firstly those who remember the history of raising antibodies for the NHS in the farmyard (literally).Secondly, it may appeal to any 'soft pinko lefties' among us who don't really like the idea of sacrificing hoards of mice or other furry creatures to run our immunoassay industry. Sorry if I get my phone tapped for that thought.The antibodies apparently are intact but lack the ability to bind Fc receptors, which may initially hinder pharmacological uses. However I would imagine that could be an advantage in immunoassays by removing potential interference from rheumatoid factor etc.http://www.rsc.org/chemistryworld/News/2006/September/04090601.aspApologies if you are doing this already.RegardsSteve
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Roger
Molecular Endocrinology
University College London Medical School
London W1N 8AA
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