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Dear Colleagues - Recently DPC has changed TSH kit. The company states "TSH kit has been reoptimized, and a sample specific negative bias has been corrected. Patient and control results may shift to higher values". We have seen upward shift in the patient samples (median with old kit = 1.49; n=4885; new kit = 2.39; n=1381) and the lab is receiving calls from physicians about slightly high TSHs (6s, 7s and 8s). Have you seen this shift? Have you reevaluated/ changed the reference ranges? Thanks. Uttam Garg, Ph.D, DABCC, DABFT, FACB Professor, University of MO Kansas City School of Medicine Director, Clinical Chemistry and Toxicology Laboratories Department of Pathology and Laboratory Medicine, Children's Mercy Hospitals and Clinics Kansas City, MO 64108. Phone: 816-234-3803; Fax: 816-802-1492 ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/