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There are two total bilirubin methods available on the Roche modular. The standard method is interfered with at a lipaemic index of 75, but the Bilirubin Total liquid method isn't interfered with until the lipaemic index is 1000. The only snag with the liquid method to my knowledge is that the it can't be used on lithium heparin samples, Regards, Damian Griffin Dr Damian Griffin Consultant Chemical Pathologist Department of Clinical Biochemistry University College Hospital, Newcastle Road, Galway, Ireland Tel: +353 (0)91 544825 Email: [log in to unmask] -----Original Message----- From: Clinical biochemistry discussion list [mailto:[log in to unmask]]On Behalf Of Lang, Tim Sent: 21 December 2006 10:01 To: [log in to unmask] Subject: Total Bilirubin and lipaemia interference in Neonatal samples Dear List, I would like to know how other laboratories deal with lipaemic samples with respect to total bilirubin assay. I am particularly interested in those labs who are supporting a SCBU or Neonatal ICU. In Belfast on the Roche, the lipaemic index is set at 75. As a lot of neonates are on continuous TPN ( with intraalipid infusion) we are finding that a proportion of sample results are being held back due to this level. A lot of these babies are also on phototherapy treatment so the total bilirubin result is essential. I would be grateful to the views of the mailbase. Thanks in advance. Tim Dr Tim Lang Principal Clinical Scientist Clinical Biochemistry Department Kelvin Building Royal Victoria Hospital Belfast BT12 6BA 02890 633064 02890 234029 (Fax) ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ The information contained in this email and in any attachments is confidential and is designated solely for the attention and use of the intended recipient(s). If you are not the intended recipient of this e-mail, you should not use,disclose, copy, distribute or retain this message or any part of it. If you have received this in error, please notify me immediately and delete all copies of this email from your computer system(s). This email has been processed by an automated anti-virus system; however it is the responsibility of the recipient to ensure that the message(and attachments)is safe and authorized for use in their own environment.