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Dear SnPM developers and users: My study is looking at the regional tissue growth during normal brain development. I calculated the annualized tissue change map based on the Jacobian map of the deformation field. Then I examined the mean at each voxel using t-test and see if it is away from zero. I want to use SnPM to correct for multiple comparisons across the whole brain volume. I followed the “fMRI Example” on the SnPM website which I thought is a very much the same application. However, I keep getting error messages. First I thought it was a memory issue. But when I cut down to two subjects, I still get error message and could not complete the analysis. I have 13 subjects and each scan has the dimension of 199 x 199 x 199. The size for each voxel is 1mm cube. I obtained the annualized tissue change maps using Matlab6 and the results were saved in the .img (unsighed int)file. The header files were generated by makeaheader command. I am running the analysis on a Windows pc (Pentium 4 CPU 3.2 GHz, 1GB of RAM). The following is an outline of the error messages. I could not diagnose the problem and hope I could find out an answer here. I greatly appreciate for your time! Xue /////// All 13 subjects were all selected /////// Warning: Assuming a scalefactor of 1 for "…\C9039_V3_AGR.img". In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol_ana.m at line 124 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m (subfunc) at line 93 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m (subfunc1) at line 62 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m (subfunc2) at line 51 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m at line 37 In C:\Documents and Settings\xhua\Desktop\SPM\snpm2\snpm_cp.m at line 198 …… similar warnings appeared for each subject. ??? Error using ==> * Out of memory. Type HELP MEMORY for your options. Error in ==> C:\Documents and Settings\xhua\Desktop\SPM\snpm2\snpm_cp.m On line 268 ==> TH = TH*ones(1,WorkDim); %-Global activities ??? Error while evaluating uicontrol Callback. ///////// Only 2 subjects were selected ////////// Warning: Assuming a scalefactor of 1 for "…\C9039_V3_AGR.img". > In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol_ana.m at line 124 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m (subfunc) at line 93 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m (subfunc1) at line 62 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m (subfunc2) at line 51 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m at line 37 In C:\Documents and Settings\xhua\Desktop\SPM\snpm2\snpm_ui.m at line 389 … SnPM: snpm_cp ======================================================================== Initialising... Warning: Assuming a scalefactor of 1 for "…\C9039_V3_AGR.img". > In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol_ana.m at line 124 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m (subfunc) at line 93 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m (subfunc1) at line 62 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m (subfunc2) at line 51 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m at line 37 In C:\Documents and Settings\xhua\Desktop\SPM\snpm2\snpm_cp.m at line 198 Warning: Assuming a scalefactor of 1 for "…\C9125_V3_AGR.img". > In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol_ana.m at line 124 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m (subfunc) at line 93 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m (subfunc1) at line 62 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m (subfunc2) at line 51 In C:\Documents and Settings\xhua\Desktop\SPM\spm2\spm_vol.m at line 37 In C:\Documents and Settings\xhua\Desktop\SPM\snpm2\snpm_cp.m at line 198 Working on correct permutation... ??? Error using ==> horzcat Out of memory. Type HELP MEMORY for your options. Error in ==> C:\Documents and Settings\xhua\Desktop\SPM\snpm2\snpm_cp.m On line 339 ==> XYZ = [ x(rem(Q-1,PlDim)+1) ... ??? Error while evaluating uicontrol Callback.