Dear experts of neuroimaging. I'd like to ask a question that how I determine the extent threshold of SPM result. According to the height threshold, the significant cluster size would vary. So, I thought ignoring the smaller clusters than intrinsic spatial resolution of SPECT scanner (6.9 mm) is irrational. But, some reviewers for my manuscript disappointed me with this problem (pointing out the small size of brain structures(i.e. hypothalamus...) -------------------------------------------------------------------------------------------------------------------- Woo Suk, Tae Neuroimaging Lab. Dept. of Neurology, Samsung Medical Center, Seoul, Korea Ph.D. Candidate, Computational Neuroimage Analysis Lab. Dept. of Biomedical Engineering, Hanyang University Tel: 82-2-3410-2738 Fax: 82-2-3410-2759 email: [log in to unmask] --------------------------------------------------------------------------------------------------------------------