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Hi George,: >We have collected fMRI data on 12 subjects, and for >each subject we have created a contrast map >(activation vs. baseline). We would now like to >perform a single-group t-test. How do we do this in >SPM2? > the one sample t-test is avaible from the 'basic model' button .. and stay in the 'fMRI side' :-) if you need more information about basic model have a look to my fMRI user guide for SPM2 http://membres.lycos.fr/wamcyril/Documents/SPM2_eng.pdf Best, Cyril