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Hi Rachel > Hi Cyril and Matthew, > > What I've done was a task-control first level analysis for each > subject and the created contrast was used in a one sample ttest for > each group, one for group A and one for group B. In this case is it ok > to pool all the data for group A + group B and create the ROIs? > > Thanks for your help, > > Rachel > So my guess was right .. you've just looked at simple effects, i.e. what is activated in each group. My answer is yes, I think that the best thing to do is to pool your task-control contrasts of group A and B ; maybe with a conjunction analysis and then define your ROI to look at the differences. For the conjunction I'm not really sure .. but Matthew is an expert. Good luck Cyril